Probability and Punnett Squares in Genetics

Statistics and probability have many applications to science. One such connection between another discipline is in the field of genetics. Many aspects of genetics are really just applied probability. We will see how a table known as a Punnett square can be used to calculate the probabilities of offspring having particular genetic traits. Some Terms from Genetics We begin by defining and discussing some terms from genetics that we will use in what follows. A variety of traits possessed by individuals are the result of a pairing of genetic material. This genetic material is referred to as alleles. As we will see, the composition of these alleles determines what trait is exhibited by an individual. Some alleles are dominant and some are recessive. An individual with one or two dominant alleles will exhibit the dominant trait. Only individuals with two copies of the recessive allele with exhibit the recessive trait. For example, suppose that for eye color there is a dominant allele B that corresponds to brown eyes and a recessive allele b that corresponds to blue eyes. Individuals with allele pairings of BB or Bb will both have brown eyes. Only individuals with pairing bb will have blue eyes. The above example illustrates an important distinction. An individual with pairings of BB or Bb will both exhibit the dominant trait of brown eyes, even though the pairings of alleles are different. Here the specific pair of alleles are known as the genotype of the individual. The trait that is displayed is called the phenotype. So for the phenotype of brown eyes, there are two genotypes. For the phenotype of blue eyes, there is a single genotype. The remaining terms to discuss pertain to the compositions of the genotypes. A genotype such as either BB or bb the alleles are identical. An individual with this type of genotype is called homozygous. For a genotype such as Bb the alleles are different from one another. An individual with this type of pairing is called heterozygous. Parents and Offspring Two parents each have a pair of alleles. Each parent contributes one of these alleles. This is how how the offspring obtains its pair of alleles. By knowing the genotypes of the parents, we can predict the probability what the offsprings genotype and phenotype will be. Essentially the key observation is that each of a parents alleles has the probability of 50% of being passed down to an offspring. Lets go back to the eye color example. If a mother and father are both brown eyed with heterozygous genotype Bb, then they each have probability of 50% of passing on the dominant allele B and a probability of 50% of passing on the recessive allele b. The following are the possible scenarios, each with probability of 0.5 x 0.5 0.25: Father contributes B and mother contributes B. The offspring has genotype BB and phenotype of brown eyes.Father contributes B and mother contributes b. The offspring has genotype Bb and phenotype of brown eyes.Father contributes b and mother contributes B. The offspring has genotype Bb and phenotype of brown eyes.Father contributes b and mother contributes b. The offspring has genotype bb and phenotype of blue eyes. Punnett Squares The above listing can be more compactly demonstrated by using a Punnett square. This type of diagram is named after Reginald C. Punnett. Although it can be used for more complicated situations than the ones that we will consider, other methods are easier to use. A Punnett square consists of a table listing all of the possible genotypes for offspring. This is dependent upon the genotypes of the parents being studied. The genotypes of these parents are typically denoted on the outside of the Punnett square.   We determine the entry in each cell in the Punnett square by looking at the alleles in the row and column of that entry. In what follows we will construct Punnett squares for all possible situations of a single trait. Two Homozygous Parents If both parents are homozygous, then all of the offspring will have an identical genotype. We see this with the Punnett square below for a cross between BB and bb.   In all that follows the parents are denoted with bold. b b B Bb Bb B Bb Bb All of the offspring are now heterozygous, with genotype of Bb. One Homozygous Parent If we have one homozygous parent, then the other is heterozygous. The resulting Punnett square is one of the following. B B B BB BB b Bb Bb Above if the homozygous parent has two dominant alleles, then all of the offspring will have the same phenotype of the dominant trait. In other words, there is a 100% probability that an offspring of such a pairing will exhibit the dominant phenotype. We could also consider the possibility that the homozygous parent possesses two recessive alleles.   Here if the homozygous parent has two recessive alleles, then half of the offspring will exhibit the recessive trait with genotype bb. The other half will exhibit the dominant trait but with heterozygous genotype Bb. So in the long run, 50% of all offspring from these types of parents b b B Bb Bb b bb bb Two Heterozygous Parents The final situation to consider is the most interesting.   This is because the probabilities that result.   If both parents are heterozygous for the trait in question, then they both have the same genotype consisting of one dominant and one recessive allele. The Punnett square from this configuration is below.   Here we see that there are three ways for an offspring to exhibit a dominant trait and one way for recessive.   This means that there is a 75% probability that an offspring will have the dominant trait and a 25% probability that an offspring will have a recessive trait. B b B BB Bb b Bb bb

How Did Shakespeare Portray the Concept Free Essays

How did Shakespeare portray a concept of honour in Henry IV part 1? In this world, there exists, since the dawn of civilisation of mankind, a thing that we are fighting and dying for—that is honour. Shakespeare explores the theme of honour in Henry IV part 1 in a rather interesting way by having it presented in a different form varying from character to character. Henry IV wants to protect his honour by using any means available to vanquish the rebels, his sinful act to King Richard also keeps haunting him and shakes his own faith in his honour. We will write a custom essay sample on How Did Shakespeare Portray the Concept or any similar topic only for you Order Now While his son’s dishonourable acts in the beginning of the play wearies him further. Superficially, one may think Prince Hal is a typical young slacker whose life has been fully lured by the glamorous but immoral world of liquor,gambling, prostitution and crime, the truth is, unbeknownst to anyone, the prince is scheming to reform himself from an idler into a more responsible and competent heir to the throne. Here, his vision of honour of behaving like the royal is an impetus for him to seek new behaviour which will bring him more merits, making him an honourable figure the status he deserves. Or Hotspur, honour is everything, ironically more valuable than his wife. His excess obsession of honour induces many political mistakes, most notably his decision to confront the king at Shreswbury despite having less number of troops. In other words, Hotspur’s passion for honour blinds him from the reality. For all his chivalry and valor in the battle, Hotspur is proved to fail at being a military strategis as well as effective leader. It is none other than the lazy, unscrupulous and coward Sir Falstaff whose existence in the play represents the values that totally oppose the fore-mentioned concepts of honour. His disenchanted view on honour can make the audiences see that the reason behind other characters’ action are single-minded and irrational or more poignantly worthless. Overall, the exhilaration of the play partially arises from Shakespeare’ way of presenting honour in various forms, paralleling the play to the real world where different people all know honour with different interpretation. King Henry IV whose name is the title of the play, is not in fact the protagonist, however the play speculates what has occurred during his turbulent reign. In Richard II, the audiences see him as dynamic and brave, indicating his kingly qualities. All the audiences must then be bewildered upon seeing him in this play. Suspicious, stressful and sick was the king after all dishonouralbe acts he did to King Richard previously. Shakespeare tries to explore how the sin of being viciously dishonourable comes back to haunt its perpetrator. Despite the king’s regret of what he did to Richard and his passion to redeem himself by going to crusade, this sin seems to block all the means for the king to purify himself. The rebellion of the Percys and rebellious nature of his son led him to grow very ill. Act one scene one, he moaned about his son and mistakenly praises Hotspur’s qualities, saying that Hotspur is â€Å"a son (of Percy) who is the theme of honour’s tongue, implying that Hal brings him with nothing but shame and disgrace. His anger even drives him further to contemplate that if he only and Northumberland could switch sons, â€Å"would have I (himself) his Harry and he mine. Fortuantely, in the end the king gains back honour by defeating the rebels and his son, who used to represent everything he scorns and acts dishonourably, has redeemed himself and proves to be an effective warrior. Henry Momouth or affectionately known as Hal is an interesting character as well as complex. At the beginning,the audiences see Hal as a drunken idler who acts nothing like an heir to the throne. Unexpectedly, Hal, in Act 1scne 2 makes it clear that he doesn’t plan to live the rest of his life in this world of immorality, in fact he claims that he is pretending to be this sort of person then when the right moment comes, he is going to transform himself into a person with all characteristics of the king. Reformation, glittering over faults, will do more goodly and attract more eyes† expresses his prediction that his â€Å"reformation† would make his subjects surprises and therefore gains more popularity for him which is necessary in order to keep the kingdom stable. Hal has a vision that the great honour of being king will at the eventually fall on him whether he likes it or not. This vision of future honour is the impetus of Hal’s self-reformation. Henry Ho tspur was a renowned warrior whose actions and decisions all have been influenced by the concept of honour. Unlike other characters, Hotspur’ was too obsessed with honour, resulting in a single-minded decision making. For all his chivalry, Hotspur was an utter political failure. Act 4 Scene 1, despite possessing less troops, HOTSPUR, without opening his mind for Worcester and Vernon’s suggrstion, decided to confront the king’s troops the next day. Moreove, this sort of obsession makes Hotspur far from being diplomatic. Whenever he is angry, he always bursts and doesn’t listen to anyone but himself. All this proves that, comparing to Hal, he is not deserved to wield the power. However, despite these differences, he and Hal share only one common belief in one respect of honor. Both of them make it clear that in order for one to gain honor, another one must die first. â€Å"Harry to Harry shall, hot horse to horse, meet and never drop til one dropped a corpse† said Hotspur in Act 4 scene 1 before the battle of shrewsbury. This line best exemplified the fore-mentioned point. Falstaff lacked any sort of honur. â€Å"what is honur? A word†, expressed Flastaff, demonstrating his disenchanted attitude towards honour. Although having been opposing this concept, at the end of act 5 scene 4, Falstaff seems to be sel-contradictory when he commented that he would embrace a new and more honourable lifestyle only if he gains honor and status after the battle. From this, it is clear that Falstaff would embrace the concept of honour only if honor comes to him first. Therefore he does not oppose honour for ideological reason but rather for practical reason as through out the play honour in anyform doesn’t seem to come to him‘ In conclusion, different characters in this play have different concepts of honour How to cite How Did Shakespeare Portray the Concept, Essay examples

Manila Chamber Singers free essay sample

The Manila Chamber Singers rehearsed prior to the formal presentation to make certain theyll satisfy the crowd and satisfaction Is an understatement-?it was an amazing performance that will leave an Indelible mark on my Inner artistic self. When the first song was showcased-?our national anthem, I knew right there and then that I got more than what I paid for. I couldnt remember the last time that the Leapfrogging gave me Goosebumps. They Introduced four spiritual songs and I thought their repertoire was Limited to this genre.I took notes on vocal dynamics since I encountered It on Hallelujah. I also Jotted one particular song-?Comprehensible since for me selling Is hard while singing good Is harder but selling a German song that good? The ensemble never ceases to amaze me. On top of that, they also did some cultural songs from local regions of our country (I. We will write a custom essay sample on Manila Chamber Singers or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Kerugma from Panky island) I took some videos since I am eager to show my musician friends the Manila Chamber Singers experience. This doesnt happen every day, so why not capture the moment? It got more entertaining when they did popular ones that even youngsters knew. Of all the songs from their set lists, Overdrive and Moonrise belong to my favorites. Overdrive has a cool bass line and Moonrise has a nice chord progression, imagine my Joy when I heard these from them. But the real surprise of the evening was when they did the medley. They got the crowd with all sorts of dancing, acts etc. I thought these type of performers were too conservative, kudos for breaking boundaries and spicing it up.

Panel Discussion free essay sample

To be honest, we felt a little disappointed when Ms. Jeanne Purpura told us minutes before our panel discussion that the projector was not available for use. In addition, we also sort of panicked because almost half of what we would deliver that day was only based and could only be delivered effectively by our powerpoint presentation. The graphs and statistics we have researched about were included in that visual aid; the audience might have enjoyed and understood the discussion more if the projector was functioning well. All the same, we still managed to get through. In fact, in my opinion, we have achieved our objective of informing the audience about mobile nuclear drive, its advantages, disadvantages and consequences to the health and welfare of the society. However, no panel discussion is perfect. In fact, no speech is flawless; everyone has his/her own strengths and weaknesses. And in this paper, I am going to discuss the strong and weak points of our panel discussion. We will write a custom essay sample on Panel Discussion or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Let me begin with the â€Å"Speaker† aspects in the rubric for panel discussion. I admit that one of the weak spots of our group was the lack of enthusiasm in our facial expressions and voice projection. We, the panel members, also failed to establish rapport with one another. However, in my opinion, my groupmates and I tried our best to be as knowledgeable as possible with regards to our assigned topic. Without a doubt, I can tell that we looked prepared and credible, not just because we are engineering students and are expected to really have some grasp of these kind of topics but because we have really researched and internalized the issue in depth. We also wore appropriate formal attire and took our respective roles as different kinds of engineers seriously. As a result of these, we had some convincing power towards the audience that I felt their eagerness to listen and learn more about our subject matter. They even asked a handful of questions and this serves as proof that they were really into our discussion. On the other hand, I confess that the flow of our discussion was not that organized. The ideas did not come in a smooth flow and I think, this was one of the consequences of not having a visual aid. In effect, the panel discussion lacked spontaneity. However, we should have adjusted with regards to that aspect for the reason that technical difficulties are inevitable and a good speaker should have seen that and have prepared for that beforehand. In the rubric, we scored relatively high in the â€Å"Message Content† part. I think it is because our arguments are supported with adequate evidence and well–researched facts and information. We failed to cite our references though, for the reason that our list of references was embedded in our powerpoint presentation. Lastly, based on the feedback we have received from our blockmates, I believe that our group has answered the questions of the audience credibly and convincingly. Next aspect would be the organization. Thanks to our moderator, Mr. Doolittle, who started and ended our panel discussion with a bang. On the other side of the coin, we failed to use transitions and the details we discussed were not that logically organized, like what I said in one of the paragraphs above. In other words, a smooth flow of ideas was not observed. Apologies. In the aspect of transmission, we also scored relatively high. There was a varied intonation and a conversational tone while we delivered the information. There was also a controlled speed delivery; we went not too fast but not too slow. In simpler words, we went at a moderate pace, so as not to hurry or lose the eagerness of the audience. When it comes to nonverbal aspects of speech delivery, our group did not fail to apply what we have learned. I noticed some simple but effective gestures while watching our video. Even the effortless movements of hands while discussing could help in transmitting what we are trying to express or say. Our group also explained the technicalities and the mechanics of nuclear power in layman’s terms so as to be understood by our blockmates who are not that familiar with our subject matter. For this reason, I think it is valid to say that we used clear language to benefit everyone. Still, we fell trap to using fillers like uhm’s and ah’s and unavoidable pauses. Sorry for those. On the bright side, there was no code-switching in our discussion. In linguistics,  code-switching  is the switching between two or more languages, or language varieties, in the context of a single conversation. In our discussion, we really tried our very best to explain the topic to our audience through he use of only one language, English. This is for the reason that English will be used when we communicate with our fellow engineers and with other professionals less than five years from now. Last would be the audience rapport. At the beginning of the discussion, our moderator formally acknowledged the presence of the audience, especially of Ms. Jeanne. Also, our group made it a point to include audience participation in our discussion. In truth, according to them, we have addressed and answered their questions and clarifications properly. Also, a big â€Å"thank you† to our moderator, Mr. Doolittle, who did well in maintaining the balance of our discussion and for adding some humor when the topic becomes serious and very technical; without him, the audience might have been bored with the endless scientific terms being bombarded to them. With this, the audience paid attention and rapport with them was established. What’s more, the fact that our topic, Mobile Nuclear Drive, was new, interesting, appealing and environment-related adds to the list of our strengths of our panel discussion. Conversely, one weak point in this aspect would be the failure of establishing and maintaining eye contact with the audience. To sum up, for the reason that we received more good comments than bad ones from our blockmates, I can say that our panel discussion was not much of a disaster even though we did not have a powerpoint presentation to aid us. Just like the previous activity, the Informative Speech, I also learned lots of lessons in this Panel Discussion activity. First, be prepared just in case a technical difficulty comes in and ruins your original plan. Always have plan B. Second, rapport is very essential when it comes to almost everything. But to be specific, audience rapport in speeches is a â€Å"must† because without it, your whole speech would be wasted because no one will listen to you. Third, know your topic from the heart. Who knows? You could be asked with heaps of questions and you should be able to answer if not all, most of them. Plus, five years from now, we might be working in a company and when it comes to project or business proposals, we should master every detail, may it be big or small, so as to gain the credibility and trust of other, even higher professionals. Lastly, there must be a logical organization of the details or the parts of your speech so as not to confuse your audience and for them to continue listening with eagerness and full attention.

History of the Iron Lung or Respirator

History of the Iron Lung or Respirator By definition, the iron lung is an airtight metal tank that encloses all of the body except the head and forces the lungs to inhale and exhale through regulated changes in air pressure. According to Robert Hall author of History of the British Iron Lung, the first scientist to appreciate the mechanics of respiration was John Mayow. John Mayow In 1670, John Mayow demonstrated that air is drawn into the lungs by enlarging the thoracic cavity. He built a model using bellows inside which was inserted a bladder. Expanding the bellows caused air to fill the bladder and compressing the bellows expelled air from the bladder. This was the principle of artificial respiration called external negative pressure ventilation or ENPV that would lead to the invention of the iron lung and other respirators. Iron Lung Respirator - Philip Drinker The first modern and practical respirator nicknamed the iron lung was invented by Harvard medical researchers Philip Drinker and Louis Agassiz Shaw in 1927. The inventors used an iron box and two vacuum cleaners to build their prototype respirator. Almost the length of a subcompact car, the iron lung exerted a push-pull motion on the chest. In 1927, the first iron lung was installed at Bellevue hospital in New York City. The first patients of the iron lung were polio sufferers with chest paralysis. Later, John Emerson improved upon Philip Drinker’s invention and invented an iron lung that cost half as much to manufacture.

E-Logistics and International Supply Chain Management Research Paper - 1

E-Logistics and International Supply Chain Management - Research Paper Example   According to the present day context, the aerospace industry of Singapore incorporates a major set of factors that are subjected to attain the interest and attention of the global marketers to expand their manufacturing plants (Low, 2001). In relation to an in-depth understanding of the case, it has been critically recognized that the external environmental factors along with adequate resources and capabilities associated with the Seletar Aerospace Park in Singapore are highly effective for the international manufacturers to produce a wide range of quality based aerospace parts with a feasible or lower amount of cost. With regard to the major motivational reasons for Rolls-Royce’s decision, a few major factors can be widely accepted behind the selection of Singapore as the production plant location for the company (Singapore Economic Development Board, 2014; Grant, 2014). The major motivational factors of the company have been briefly described in the following section.Acc ording to the observation of the article, it has been identified that the political factor is one of the key driving factors for Rolls-Royce to select Singapore as its plant location for manufacturing titanium fan blades (Grant, 2014). The adequate stability along with transparent political system and practices of Singapore is more sophisticated as compared to the other developing nations that can enable the organization to independently perform its manufacturing operations with a minimum or less numb of constraints.   

Business Law - Use of Contracts in E-commerce Assignment

Business Law - Use of Contracts in E-commerce - Assignment Example Business transaction costs can be reduced by low communication cost strategy. It can allow the organizations to focus on their core business activities (Lee, 1998, p.4). Moreover, organization can buy several external services through this cost reduction strategy. Frauds and opportunistic behaviour can take place in a strong long-term relationship between two different organizations. Supreme mutual trust can pose limited risk. Moreover, it will help the organizations to reduce their risk management costs. E-commerce involves synchronization between several organizations implementing effective communication technology. This synchronization can be attained in the form of a virtual enterprise or an electronic enterprise. Contracts play an important role in both these cases. In global electronic market, contracts are referred as the agreements on a particular business transaction. Contract can be considered as the collaboration agreement for a longer time period in a virtual enterprise. These cooperation agreements involve integrated business process. This integration can be attained in several ways but generally shared database and inter-organizational workflows are the major sources of this integrated business process. The study will discuss the use of several contracts in the e-commerce business. Content A contract can be defined as an agreement between several parties that is based on specific mutual commitments. One-sided commitment cannot be considered as a contract. Exchange of several goods and services between two or more than two parties can be termed as mutual commitment. In most general cases, one party provides services or goods and other party pays for those exchanged goods and services. Moreover, enforcement mechanism in places is highly essential in a contract. It ensures both identification and punishment of breaking a promise or commitment. As of now, every contract can be made through online in UK. Business transactions are generally divided into three successive phases, such as contract preparation, contract negotiation and contract fulfilment (Daskalopulu and Sergot, 1997, pp. 6-8). Contract preparation can be referred as the information phase. On the other hand, contract recognition can be referred as agreement phase. Contract fulfilment phase has limited negotiation activities. In this phase, several buyers select a specific product or service. It indicates that the buyers want to purchase that product or service. On the other hand, sellers deliver the product or services to the buyers after, before, or at the time of payment. This exchange process becomes more complicated in B2B process as the price of products or services may be not fixed. Moreover, the delivery process can become more difficult in several B2B processes as in International Trade. In these situations, the contracts are more elaborative in nature. These include several specifications in some fulfilment processes’ form (Chirku and Kauffman, 2000, pp.7-12). Moreover, these contracts help to indicate the disputes’ resolve process. Legal system is struggling due to rapid pace of e-commerce development. It is discussed earlier that mutual exchange of goods and services can be referred as contract. Written contract is the e-commerce legal tool. These contracts can